Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1189)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0815861	0.0998201	0.4229155
Weighted median	23	-0.0092956	0.0567159	0.8698116
Inverse variance weighted	23	-0.0703247	0.0390153	0.0714684
Simple mode	23	0.0423629	0.1067101	0.6951992
Weighted mode	23	0.0113764	0.0809889	0.8895682

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.57369	21	0.8872058
Inverse variance weighted	13.58871	22	0.9154319

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0006916	0.0056424	0.9036151

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005102	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8