Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1188)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0915968	0.1218614	0.4606048
Weighted median	23	0.1212392	0.0618891	0.0501158
Inverse variance weighted	23	0.0346744	0.0468199	0.4589407
Simple mode	23	0.1420845	0.1296374	0.2849256
Weighted mode	23	0.1505792	0.0834777	0.0849704

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.29884	21	0.0688263
Inverse variance weighted	31.68267	22	0.0829694

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0034956	0.0068883	0.6171086

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000984	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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