Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1187)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1388841	0.0998187	0.1786810
Weighted median	23	0.0126750	0.0591727	0.8303887
Inverse variance weighted	23	0.0183114	0.0390151	0.6388259
Simple mode	23	0.0086376	0.0970875	0.9299126
Weighted mode	23	-0.0019213	0.0861548	0.9824097

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.82250	21	0.5965254
Inverse variance weighted	20.54466	22	0.5490101

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0074044	0.0056423	0.2035791

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006292	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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