Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1186)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1247342	0.0998204	0.2251993
Weighted median	23	0.0745346	0.0524981	0.1556777
Inverse variance weighted	23	0.0599039	0.0390157	0.1246906
Simple mode	23	-0.0114176	0.0812895	0.8895781
Weighted mode	23	0.0670324	0.0598003	0.2744017

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.74062	21	0.8357383
Inverse variance weighted	15.23849	22	0.8518015

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0039812	0.0056424	0.4881916

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005332	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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