Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1185)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0026424	0.0998205	0.9791309
Weighted median	23	-0.0501468	0.0572460	0.3810365
Inverse variance weighted	23	-0.0202005	0.0390156	0.6046297
Simple mode	23	-0.1185666	0.0956833	0.2283454
Weighted mode	23	-0.0279311	0.0635722	0.6646859

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.66091	21	0.5428209
Inverse variance weighted	19.72272	22	0.6003792

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0014028	0.0056423	0.806072

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006058	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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