Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1184)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1920359	0.1106578	0.0973224
Weighted median	23	0.0640249	0.0570053	0.2613786
Inverse variance weighted	23	0.0411078	0.0444117	0.3546494
Simple mode	23	0.0505705	0.1333096	0.7080676
Weighted mode	23	0.1207743	0.0765352	0.1288325

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.80850	21	0.2138451
Inverse variance weighted	28.50698	22	0.1594819

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0092686	0.006255	0.1532458

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008975	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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