Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1183)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0892266	0.0998209	0.3815234
Weighted median	23	-0.0308360	0.0539454	0.5675828
Inverse variance weighted	23	-0.0021735	0.0390158	0.9555750
Simple mode	23	-0.0640801	0.0861949	0.4650856
Weighted mode	23	-0.0621177	0.0657488	0.3550360

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	11.18586	21	0.9590439
Inverse variance weighted	12.08355	22	0.9556295

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0053459	0.0056424	0.354179

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003662	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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