Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1182)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0779067	0.0998199	0.4438220
Weighted median	23	0.0153229	0.0558898	0.7839600
Inverse variance weighted	23	-0.0064996	0.0390156	0.8676919
Simple mode	23	0.0901630	0.0981467	0.3682386
Weighted mode	23	0.0757887	0.0711918	0.2986160

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.44902	21	0.6204391
Inverse variance weighted	19.05303	22	0.6420516

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0043851	0.0056423	0.4457179

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005782	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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