Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1181)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0429273	0.1149315	0.7125179
Weighted median	23	0.0055732	0.0557019	0.9203019
Inverse variance weighted	23	0.0096825	0.0441468	0.8263975
Simple mode	23	-0.0854674	0.0947037	0.3765818
Weighted mode	23	-0.0169440	0.0662211	0.8004288

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.83955	21	0.1447608
Inverse variance weighted	28.16742	22	0.1701990

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0032307	0.0064964	0.6241378

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008554	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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