Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1180)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1669649	0.0998204	0.1092294
Weighted median	23	-0.0007176	0.0547432	0.9895413
Inverse variance weighted	23	0.0135660	0.0407168	0.7389983
Simple mode	23	-0.0241005	0.0934126	0.7988044
Weighted mode	23	-0.0182571	0.0608307	0.7668964

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.09990	21	0.5149418
Inverse variance weighted	23.96057	22	0.3492998

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0110864	0.0056423	0.0627986

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007297	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8