Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 118)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0115682	0.0998197	0.9088397
Weighted median	23	0.0986871	0.0532430	0.0638076
Inverse variance weighted	23	0.1204852	0.0390155	0.0020142
Simple mode	23	0.0818470	0.0888880	0.3671487
Weighted mode	23	0.0510368	0.0611523	0.4129227

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	11.77521	21	0.9454885
Inverse variance weighted	13.84090	22	0.9070295

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0081094	0.0056423	0.1653801

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007084	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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