Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1179)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0642826	0.0998195	0.5265550
Weighted median	23	-0.0030804	0.0571703	0.9570303
Inverse variance weighted	23	0.0063912	0.0390156	0.8698788
Simple mode	23	0.0452426	0.1064819	0.6750470
Weighted mode	23	-0.0246328	0.0760700	0.7491345

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.64865	21	0.7890560
Inverse variance weighted	16.24033	22	0.8037818

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0043401	0.0056423	0.4503363

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000493	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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