Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1178)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0213164	0.1126676	0.8517550
Weighted median	23	0.0681161	0.0559185	0.2231745
Inverse variance weighted	23	0.0099800	0.0431178	0.8169573
Simple mode	23	0.0776090	0.0886767	0.3909255
Weighted mode	23	0.0672878	0.0599800	0.2740266

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.75334	21	0.1791675
Inverse variance weighted	26.86937	22	0.2162302

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0019219	0.0063685	0.7657856

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008162	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8