Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1177)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1087854	0.1046723	0.3104866
Weighted median	23	-0.0640043	0.0606899	0.2916029
Inverse variance weighted	23	-0.0575688	0.0402394	0.1525278
Simple mode	23	-0.0208198	0.1016264	0.8395606
Weighted mode	23	-0.0015146	0.0769798	0.9844796

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.09142	21	0.3391234
Inverse variance weighted	23.40215	22	0.3793274

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0031452	0.0059166	0.6005879

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007751	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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