Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1176)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0135942	0.1194611	0.9104807
Weighted median	23	-0.0017831	0.0559992	0.9745987
Inverse variance weighted	23	0.0255047	0.0457557	0.5772475
Simple mode	23	0.0295346	0.0821539	0.7226461
Weighted mode	23	0.0057251	0.0581338	0.9224422

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.07673	21	0.0904568
Inverse variance weighted	30.25782	22	0.1123315

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.002401	0.0067525	0.7257024

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009298	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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