Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1175)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0327737	0.0998202	0.7459155
Weighted median	23	0.0212860	0.0576270	0.7118479
Inverse variance weighted	23	0.0012960	0.0390156	0.9735017
Simple mode	23	-0.0032288	0.0862861	0.9704877
Weighted mode	23	0.0311530	0.0683099	0.6528212

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.21148	21	0.9010361
Inverse variance weighted	13.32885	22	0.9235821

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.001933	0.0056423	0.7353066

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004039	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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