Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1174)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0224733	0.0998212	0.8240502
Weighted median	23	-0.0348788	0.0545573	0.5226248
Inverse variance weighted	23	-0.0537759	0.0390159	0.1681083
Simple mode	23	0.0214445	0.0883958	0.8105657
Weighted mode	23	-0.0180714	0.0601351	0.7666074

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.02511	21	0.9077418
Inverse variance weighted	13.14118	22	0.9291489

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0019223	0.0056424	0.7367234

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004558	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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