Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1173)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1090024	0.1430098	0.4544158
Weighted median	23	-0.0461637	0.0558316	0.4083287
Inverse variance weighted	23	0.0343244	0.0561317	0.5408706
Simple mode	23	-0.0526001	0.0933954	0.5789959
Weighted mode	23	-0.0606533	0.0597088	0.3207578

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	43.10405	21	0.0030487
Inverse variance weighted	45.53748	22	0.0022669

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0088016	0.0080835	0.2885664

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014032	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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