Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1172)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0051072	0.1021897	0.9606128
Weighted median	23	0.0946131	0.0564898	0.0939594
Inverse variance weighted	23	0.0871692	0.0397243	0.0282098
Simple mode	23	0.1601079	0.0934384	0.1006764
Weighted mode	23	0.1375478	0.0726388	0.0715058

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.00904	21	0.3989889
Inverse variance weighted	22.80676	22	0.4127089

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0050394	0.0057763	0.392836

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008424	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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