Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1171)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1117866	0.0998196	0.2754073
Weighted median	23	0.0466036	0.0577080	0.4193344
Inverse variance weighted	23	0.0402680	0.0390154	0.3020235
Simple mode	23	0.1466808	0.0977594	0.1477198
Weighted mode	23	0.0921112	0.0627696	0.1564057

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.74334	21	0.4747114
Inverse variance weighted	21.34925	22	0.4992531

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.004392	0.0056423	0.4450154

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006792	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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