Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1170)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1024171	0.1277739	0.4317903
Weighted median	23	-0.1290615	0.0595718	0.0302739
Inverse variance weighted	23	-0.0329264	0.0491973	0.5033214
Simple mode	23	-0.1740242	0.1244210	0.1758509
Weighted mode	23	-0.1229928	0.0681188	0.0846902

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.40953	21	0.0327430
Inverse variance weighted	34.98157	22	0.0389172

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0042674	0.0072224	0.5609209

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010816	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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