Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 117)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2286106	0.0998173	0.0324549
Weighted median	23	0.0843808	0.0587240	0.1507447
Inverse variance weighted	23	0.0847849	0.0390148	0.0297693
Simple mode	23	0.0587931	0.0932234	0.5347542
Weighted mode	23	0.0724754	0.0742823	0.3398324

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.96460	21	0.7132497
Inverse variance weighted	19.41514	22	0.6195725

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0088325	0.0056422	0.1324297

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007314	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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