Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1169)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1073502	0.0998190	0.2943753
Weighted median	23	-0.0821077	0.0540330	0.1286152
Inverse variance weighted	23	-0.0459696	0.0390153	0.2386983
Simple mode	23	-0.0988150	0.1122134	0.3880539
Weighted mode	23	-0.1249889	0.0838280	0.1501574

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.31471	21	0.9307295
Inverse variance weighted	12.76102	22	0.9396126

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0037694	0.0056423	0.5113698

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004288	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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