Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1168)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0636960	0.0998208	0.5303039
Weighted median	23	-0.0708237	0.0535529	0.1860018
Inverse variance weighted	23	-0.0036107	0.0390156	0.9262656
Simple mode	23	0.0065602	0.0843416	0.9387048
Weighted mode	23	-0.0844975	0.0669806	0.2203332

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.16426	21	0.5108789
Inverse variance weighted	20.59192	22	0.5460655

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0036898	0.0056424	0.52024

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006242	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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