Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1167)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1085740	0.0998192	0.2890516
Weighted median	23	0.0013909	0.0551257	0.9798703
Inverse variance weighted	23	-0.0144362	0.0390154	0.7113730
Simple mode	23	0.0667476	0.0969765	0.4984665
Weighted mode	23	0.0087508	0.0797914	0.9136647

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.54693	21	0.5500989
Inverse variance weighted	20.59671	22	0.5457670

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.005781	0.0056423	0.3172156

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006283	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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