Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1166)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0401967	0.0998204	0.6912460
Weighted median	23	-0.0189502	0.0587697	0.7471132
Inverse variance weighted	23	-0.0190489	0.0390154	0.6253795
Simple mode	23	-0.0602462	0.1027036	0.5634415
Weighted mode	23	-0.0234254	0.0782771	0.7675487

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.11620	21	0.5776861
Inverse variance weighted	19.53199	22	0.6122892

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0036383	0.0056423	0.5260285

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005991	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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