Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1165)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1181494	0.0998206	0.2497902
Weighted median	23	0.0102424	0.0555693	0.8537648
Inverse variance weighted	23	0.0664262	0.0390157	0.0886526
Simple mode	23	0.0462203	0.0921459	0.6209323
Weighted mode	23	-0.0059279	0.0655389	0.9287492

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.1005	21	0.7639778
Inverse variance weighted	20.1361	22	0.5745267

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0113347	0.0056423	0.0575795

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000698	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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