Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1164)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2137189	0.1024330	0.0493195
Weighted median	23	0.0473409	0.0597202	0.4279464
Inverse variance weighted	23	0.0375384	0.0422434	0.3742066
Simple mode	23	0.0596272	0.1013674	0.5623699
Weighted mode	23	0.0564949	0.0692014	0.4230327

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.11384	21	0.3929754
Inverse variance weighted	25.79072	22	0.2607757

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0108192	0.00579	0.0756923

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008096	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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