Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1163)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0902885	0.1345109	0.5093874
Weighted median	23	0.0189276	0.0555171	0.7331544
Inverse variance weighted	23	0.0525066	0.0529677	0.3215421
Simple mode	23	0.0344921	0.0942694	0.7179433
Weighted mode	23	0.0273730	0.0753221	0.7197655

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.13355	21	0.0124319
Inverse variance weighted	40.54900	22	0.0093203

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0087691	0.0076032	0.2617322

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012834	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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