Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1162)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1666332	0.1162381	0.1664229
Weighted median	23	0.0053038	0.0574929	0.9264986
Inverse variance weighted	23	-0.0002984	0.0468732	0.9949206
Simple mode	23	0.0231094	0.1001864	0.8197074
Weighted mode	23	-0.0177102	0.0662271	0.7916393

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.47668	21	0.1271427
Inverse variance weighted	31.75415	22	0.0816852

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0102145	0.0065703	0.1349705

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009622	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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