Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1161)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0760725	0.1070579	0.4851661
Weighted median	23	-0.0053117	0.0591612	0.9284597
Inverse variance weighted	23	0.0316494	0.0410798	0.4410407
Simple mode	23	-0.0445369	0.0983554	0.6551154
Weighted mode	23	-0.0212069	0.0707786	0.7672775

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.15594	21	0.2855641
Inverse variance weighted	24.38971	22	0.3271381

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.002728	0.0060514	0.6567496

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000759	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8