Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1160)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0193727	0.0998204	0.8479818
Weighted median	23	-0.0049387	0.0569875	0.9309392
Inverse variance weighted	23	0.0057992	0.0390156	0.8818397
Simple mode	23	-0.0075538	0.0951694	0.9374542
Weighted mode	23	-0.0167216	0.0684400	0.8092437

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.82817	21	0.4694800
Inverse variance weighted	20.90323	22	0.5267256

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0015458	0.0056423	0.7867879

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006341	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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