Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 116)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0830027	0.1292175	0.5275978
Weighted median	23	0.0065936	0.0638122	0.9177027
Inverse variance weighted	23	0.0161651	0.0501551	0.7472243
Simple mode	23	0.0604619	0.1235782	0.6295001
Weighted mode	23	-0.0356178	0.0971731	0.7174642

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.19190	21	0.0268957
Inverse variance weighted	36.35689	22	0.0277959

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0060899	0.007304	0.413791

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011069	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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