Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1159)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0731047	0.0998205	0.4720433
Weighted median	23	-0.0369582	0.0593821	0.5336922
Inverse variance weighted	23	0.0032846	0.0390155	0.9329084
Simple mode	23	0.0044541	0.1006077	0.9650872
Weighted mode	23	-0.0338967	0.0754917	0.6578149

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.87867	21	0.7764289
Inverse variance weighted	16.56990	22	0.7866311

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0046911	0.0056424	0.4150997

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005023	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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