Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1158)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2784524	0.0998186	0.0109831
Weighted median	23	0.0410248	0.0565445	0.4681263
Inverse variance weighted	23	0.0259402	0.0427884	0.5443524
Simple mode	23	-0.0023927	0.1016513	0.9814331
Weighted mode	23	0.0605742	0.0654923	0.3650501

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.90750	21	0.5910739
Inverse variance weighted	26.46089	22	0.2324206

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0155068	0.0056422	0.0120433

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008152	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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