Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1157)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1241362	0.1106195	0.2744491
Weighted median	23	-0.0240325	0.0572412	0.6745969
Inverse variance weighted	23	0.0096903	0.0439454	0.8254766
Simple mode	23	0.0239056	0.0947858	0.8032224
Weighted mode	23	-0.0294362	0.0625462	0.6425369

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.78955	21	0.2145872
Inverse variance weighted	27.91105	22	0.1786478

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0082183	0.0062527	0.2029061

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008476	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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