Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1156)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1705218	0.1100025	0.1360427
Weighted median	23	0.1455486	0.0564295	0.0099001
Inverse variance weighted	23	0.0931960	0.0425863	0.0286400
Simple mode	23	0.1691345	0.0908390	0.0760273
Weighted mode	23	0.1691345	0.0654161	0.0168778

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.50380	21	0.2260038
Inverse variance weighted	26.21212	22	0.2426863

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0047486	0.0062179	0.4535431

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009672	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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