Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1155)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1611630	0.1006621	0.1243074
Weighted median	23	-0.0852005	0.0531648	0.1090287
Inverse variance weighted	23	-0.0595115	0.0395261	0.1321629
Simple mode	23	-0.0908845	0.0914722	0.3312328
Weighted mode	23	-0.0908845	0.0599632	0.1438401

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.35566	21	0.4374162
Inverse variance weighted	22.57967	22	0.4257792

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0062424	0.0056899	0.2850188

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007547	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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