Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1154)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2141265	0.1144058	0.0752528
Weighted median	23	-0.0748016	0.0615015	0.2238867
Inverse variance weighted	23	-0.0199202	0.0470936	0.6723007
Simple mode	23	0.0552888	0.1192486	0.6474582
Weighted mode	23	-0.0687920	0.0766748	0.3793298

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.58608	21	0.1522856
Inverse variance weighted	32.05394	22	0.0764810

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0119263	0.0064668	0.0793053

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009792	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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