Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1153)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0476172	0.1323586	0.7226200
Weighted median	23	-0.0488951	0.0586636	0.4045724
Inverse variance weighted	23	-0.0124514	0.0508352	0.8065057
Simple mode	23	-0.1491635	0.1142737	0.2052719
Weighted mode	23	-0.0540435	0.0678773	0.4344270

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.92209	21	0.0171840
Inverse variance weighted	37.34951	22	0.0216488

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0036888	0.0074815	0.6270914

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011348	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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