Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1152)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1504579	0.0998210	0.1466363
Weighted median	23	0.0262987	0.0518200	0.6118027
Inverse variance weighted	23	0.0014584	0.0390158	0.9701818
Simple mode	23	0.0721806	0.0836658	0.3975961
Weighted mode	23	0.0520558	0.0603108	0.3973809

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.24284	21	0.9328289
Inverse variance weighted	14.87265	22	0.8676451

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.00915	0.0056424	0.1197931

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004507	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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