Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1151)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0735643	0.0998211	0.4693001
Weighted median	23	0.0319453	0.0556927	0.5662394
Inverse variance weighted	23	0.0552614	0.0390159	0.1566637
Simple mode	23	0.0001958	0.0810024	0.9980930
Weighted mode	23	0.0207691	0.0632774	0.7458470

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.97676	21	0.7709554
Inverse variance weighted	17.94265	22	0.7093832

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0079111	0.0056424	0.1754943

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006045	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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