Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1150)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0138875	0.1244721	0.9122229
Weighted median	23	0.0041547	0.0573646	0.9422622
Inverse variance weighted	23	0.0614368	0.0477263	0.1979991
Simple mode	23	0.0130624	0.0914771	0.8877522
Weighted mode	23	-0.0116932	0.0601880	0.8477405

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.65278	21	0.0502118
Inverse variance weighted	32.92060	22	0.0629994

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.00292	0.0070358	0.6823361

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010726	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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