Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 115)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2170781	0.0998190	0.0412250
Weighted median	23	-0.0284815	0.0605302	0.6379737
Inverse variance weighted	23	0.0168808	0.0433775	0.6971570
Simple mode	23	0.0973096	0.1174709	0.4163567
Weighted mode	23	-0.0988922	0.0755082	0.2038141

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.71037	21	0.4767494
Inverse variance weighted	27.19451	22	0.2039317

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0143675	0.0056423	0.0187903

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008297	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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