Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1149)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0842926	0.1210037	0.4936849
Weighted median	23	0.0141399	0.0614454	0.8179973
Inverse variance weighted	23	-0.0258952	0.0472728	0.5838408
Simple mode	23	-0.1422104	0.1161406	0.2337263
Weighted mode	23	0.0335108	0.0727522	0.6495956

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.85995	21	0.0760205
Inverse variance weighted	32.29824	22	0.0724516

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0067666	0.0068397	0.3337712

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009921	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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