Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1148)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1982430	0.0998190	0.0602388
Weighted median	23	0.1561304	0.0529224	0.0031759
Inverse variance weighted	23	0.1311599	0.0390152	0.0007744
Simple mode	23	0.1913820	0.0801477	0.0259641
Weighted mode	23	0.1567049	0.0637442	0.0223007

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.66920	21	0.8833849
Inverse variance weighted	14.20228	22	0.8941445

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0041196	0.0056423	0.4733785

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007728	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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