Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1147)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0518152	0.0998210	0.6091316
Weighted median	23	-0.0254171	0.0552826	0.6456840
Inverse variance weighted	23	-0.0658074	0.0390159	0.0916644
Simple mode	23	0.0108189	0.0902827	0.9057023
Weighted mode	23	-0.0104789	0.0561694	0.8537166

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.28987	21	0.7531496
Inverse variance weighted	17.92871	22	0.7102065

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0072232	0.0056423	0.2144455

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006295	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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