Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1146)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0073424	0.1125498	0.9486026
Weighted median	23	-0.0206026	0.0627116	0.7425116
Inverse variance weighted	23	-0.0317122	0.0430361	0.4611980
Simple mode	23	-0.1424990	0.1222102	0.2560936
Weighted mode	23	0.0389767	0.0840189	0.6472741

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.69783	21	0.1810803
Inverse variance weighted	26.76818	22	0.2201639

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0014966	0.0063619	0.8163029

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008312	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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