Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1145)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0753179	0.1064321	0.4869356
Weighted median	23	-0.0082430	0.0552870	0.8814786
Inverse variance weighted	23	0.0131883	0.0414257	0.7502108
Simple mode	23	-0.0008026	0.0933037	0.9932141
Weighted mode	23	-0.0248286	0.0606627	0.6862842

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.87401	21	0.2992029
Inverse variance weighted	24.80193	22	0.3066404

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0054351	0.006016	0.376538

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000755	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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