Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1144)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1546218	0.1208397	0.2146564
Weighted median	23	0.0777937	0.0617465	0.2077095
Inverse variance weighted	23	-0.0256038	0.0489458	0.6009013
Simple mode	23	0.1309515	0.1155604	0.2693347
Weighted mode	23	0.1342600	0.0951909	0.1723962

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.77766	21	0.0774387
Inverse variance weighted	34.62563	22	0.0423774

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0110678	0.0068305	0.1200784

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010623	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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